Projects

Longitudinal Multi-omic Biomarkers for Neurocognitive Decline Prior to Dementia Onset 09/30/2024 to 06/30/2029

This project is performing the first large-scale investigation of cutting-edge proteomic measures as predictors of within-person cognitive change. Project Number: U01AG083829

Large-scale Genomic Analysis of Aging-related Cognitive Change Prior to Dementia Onset 8/15/2021 to 7/31/2026

This project is combining data across over 30 longitudinal cohorts to produce the first well-powered estimates of genetic effects on cognitive change. Project Number: R01AG073593

Differential Diagnosis in Learning Disabilities 7/1/23 to 6/30/28

The goal of this center grant is to produce comprehensive neurobiological models of learning disorders. This includes applications of Genomic SEM supervised by Co-I Grotzinger. Project Number: HD027802

Dissecting the Multivariate Genetic Architecture of Psychiatric Diseases 07/17/2020 to 04/30/2025

This project validated extensions of Genomic SEM (T-SEM; Stratified Genomic SEM) and empirically applied these methods to GWAS of psychiatric disorders and clinical correlates. Project Number: R01MH120219

Mapping Genomics to Brain Structure, Psychiatric Disorders, and Therapeutic Targets 1/1/2022 to 12/31/23

This project examined links between GWAS of different regions of the cerebral cortex and psychiatric disorders and identified genes whose expression was associated with transdiagnostic risk pathways and whose protein products are targeted by existing pharmacological interventions. Project Funding: Tommy Fuss Foundation Private Grant (Smoller)