Research

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Highlighted

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Andrew D. Grotzinger, Mijke Rhemtulla, Ronald de Vlaming, Stuart J. Ritchie, Travis T. Mallard, …, Ian J. Deary, Philipp D. Koellinger, K. Paige Harden, Michel G. Nivard, Elliot M. Tucker-Drob

Nature Human Behaviour  ·  08 Apr 2019  ·  doi:10.1038/s41562-019-0566-x

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2025

Domains of Frailty as Early Risk Factors for Alzheimer Dementia - Genetic and Causal Evidence

Jonny P Flint, Isabelle F Foote, David D Ward, Tom C Russ, Alan Marshall, Md Rezanur Rahman, Simon R Cox, Michelle Luciano, Michelle K Lupton

Cold Spring Harbor Laboratory  ·  19 Sep 2025  ·  doi:10.1101/2025.09.17.25336027

The contribution of Apoliproprotein E genetic variation to dementia risk in British South Asians

Benjamin M Jacobs, Avinash Chandra, Arnab Mandal, Isabelle Foote, Faiza Durrani, …, Moneeza Siddiqui, Sarah Finer, Stuart Rison, David A van Heel, Charles R Marshall

Cold Spring Harbor Laboratory  ·  07 Sep 2025  ·  doi:10.1101/2025.09.04.25334903

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling

Isabelle F. Foote, Jonny P. Flint, Anna E. Fürtjes, Jeremy M. Lawrence, Donncha S. Mullin, …, Janice M. Ranson, Simon R. Cox, Michelle Luciano, Kenneth Rockwood, Andrew D. Grotzinger

Nature Genetics  ·  01 Aug 2025  ·  doi:10.1038/s41588-025-02269-0

Multimorbidity in dementia: Current perspectives and future challenges

Lucy E. Stirland, Radmila Choate, Preeti Pushpalata Zanwar, Panpan Zhang, Tamlyn J Watermeyer, …, Katheryn A. Q. Cousins, Joe Butler, Abrar AbuHamdia, Thiago J. Avelino‐Silva, Vidyani Suryadevara

Alzheimer's & Dementia  ·  01 Aug 2025  ·  doi:10.1002/alz.70546

Context-based evidence: Pilot study to extract, repurpose, and distribute published data on OUD

Alexander Sheppard, Carly Milliren, Douglas Schatz, David Krag

Journal of Opioid Management  ·  01 Aug 2025  ·  doi:10.5055/jom.0948

Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI

Anna E. Fürtjes, Isabelle F. Foote, Charley Xia, Gail Davies, Joanna Moodie, …, Michelle Luciano, W. David Hill, Ian J. Deary, Elliot M. Tucker-Drob, Simon R. Cox

Nature Communications  ·  21 Jul 2025  ·  doi:10.1038/s41467-025-61978-6

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

Sophie Breunig, Younga Heather Lee, Elizabeth W. Karlson, Arjun Krishnan, Jeremy M. Lawrence, Lukas S. Schaffer, Andrew D. Grotzinger

Translational Psychiatry  ·  21 Jul 2025  ·  doi:10.1038/s41398-025-03470-9

Social determinants of dementia: A scoping review

Sebastian Walsh, Matthias Klee, Esther K. Hui, Usman Saeed, Sheena Waters, …, Eugene Y. H. Tang, David J. Llewellyn, Isabelle F. Foote, Scott T. Chiesa, Anouk F. J. Geraets

Alzheimer's & Dementia  ·  01 Jul 2025  ·  doi:10.1002/alz.70524

Depression and dementia: interrogating the causality of the relationship

Alvar Paris, Guru Amirthalingam, Tasvee Karania, Isabelle F Foote, Ruth Dobson, Alastair J Noyce, Charles R Marshall, Sheena Waters

Journal of Neurology, Neurosurgery & Psychiatry  ·  11 Jan 2025  ·  doi:10.1136/jnnp-2024-334675

Frailty Trajectories Preceding Dementia in the US and UK

David D. Ward, Jonny P. Flint, Thomas J. Littlejohns, Isabelle F. Foote, Marco Canevelli, …, David J. Llewellyn, Janice M. Ranson, Ruth E. Hubbard, Kenneth Rockwood, Erwin Stolz

JAMA Neurology  ·  01 Jan 2025  ·  doi:10.1001/jamaneurol.2024.3774

Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modelling

Inês Almeida e Sousa, Andrew D Grotzinger, Jeremy M Lawrence, Sophie Breunig, Charles R Marshall, Ania Korszun, Isabelle F Foote

Brain Communications  ·  01 Jan 2025  ·  doi:10.1093/braincomms/fcaf112

2024

Next generation brain health: transforming global research and public health to promote prevention of dementia and reduce its risk in young adult populations

Francesca R Farina, Katie Bridgeman, Sarah Gregory, Lucía Crivelli, Isabelle F Foote, …, Antonella Santuccione Chadha, Oliver M Shannon, Li Su, Wendy Weidner, Laura Booi

The Lancet Healthy Longevity  ·  01 Dec 2024  ·  doi:10.1016/j.lanhl.2024.100665

Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis

Lukas S. Schaffer, Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Andrew D. Grotzinger

Molecular Autism  ·  15 Oct 2024  ·  doi:10.1186/s13229-024-00624-2

Socioemotional Dysfunction From Temporal Lobe Involvement in Frontotemporal Dementia: A Preliminary Report

Kelsey A. Holiday, Alexander Sheppard, Youssef I. Khattab, Diana Chavez, Rebecca J. Melrose, Mario F. Mendez

The Journal of Neuropsychiatry and Clinical Neurosciences  ·  01 Oct 2024  ·  doi:10.1176/appi.neuropsych.20230175

Shared Genetic Liability across Systems of Psychiatric and Physical Illness

Jeremy M. Lawrence, Isabelle F. Foote, Sophie Breunig, Lukas S. Schaffer, Travis T. Mallard, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  04 Aug 2024  ·  doi:10.1101/2024.08.02.24311427

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

Sophie Breunig, Younga Heather Lee, Elizabeth W. Karlson, Arjun Krishnan, Jeremy M. Lawrence, Lukas S. Schaffer, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  19 Jul 2024  ·  doi:10.1101/2024.07.18.24310651

Childhood adiposity underlies numerous adult brain traits commonly attributed to midlife obesity

Scott T Chiesa, Lydia Rader, Victoria Garfield, Isabelle Foote, Sana Suri, George Davey Smith, Alun D Hughes, Tom G Richardson

Brain  ·  18 Jun 2024  ·  doi:10.1093/brain/awae198

Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis

Lukas S. Schaffer, Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  09 Jun 2024  ·  doi:10.1101/2024.06.07.24308616

Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood

Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Hannah J. Gebhardt, Erik G. Willcutt, Andrew D. Grotzinger

Biological Psychiatry Global Open Science  ·  01 May 2024  ·  doi:10.1016/j.bpsgos.2024.100307

2023

Genomic SEM applied to explore etiological divergences in bipolar subtypes

Jeremy M. Lawrence, Sophie Breunig, Isabelle F. Foote, Connor B. Tallis, Andrew D. Grotzinger

Psychological Medicine  ·  27 Oct 2023  ·  doi:10.1017/s0033291723002957

Artificial intelligence for dementia prevention

Danielle Newby, Vasiliki Orgeta, Charles R. Marshall, Ilianna Lourida, Christopher P. Albertyn, …, Anja K. Leist, Eugene Y. H. Tang, Xin You Tai, David J. Llewellyn, Janice M. Ranson

Alzheimer's & Dementia  ·  14 Oct 2023  ·  doi:10.1002/alz.13463

Jargonaphasia in logopenic variant primary progressive aphasia

Mario F. Mendez, Alexander Sheppard, Diana Chavez, Kelsey A. Holiday

Journal of the Neurological Sciences  ·  01 Oct 2023  ·  doi:10.1016/j.jns.2023.120779

Artificial intelligence for dementia genetics and omics

Conceicao Bettencourt, Nathan Skene, Sara Bandres‐Ciga, Emma Anderson, Laura M. Winchester, …, Stefano Tamburin, Carlo Sala Frigerio, Ilianna Lourida, Janice M. Ranson, David J. Llewellyn

Alzheimer's & Dementia  ·  22 Aug 2023  ·  doi:10.1002/alz.13427

Examining Differences in the Genetic and Functional Architecture of ADHD Diagnosed in Childhood and Adulthood

Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Hannah J. Gebhardt, Erik G. Willcutt, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  07 Aug 2023  ·  doi:10.1101/2023.08.02.23293439

Trans‐ethnic genomic informed risk assessment for Alzheimer's disease: An International Hundred K+ Cohorts Consortium study

Patrick M. Sleiman, Hui‐Qi Qu, John J. Connolly, Frank Mentch, Alexandre Pereira, …, Charles R. Marshall, Adam Butterworth, Bram P. Prins, Joseph T. Glessner, Hakon Hakonarson

Alzheimer's & Dementia  ·  14 Jul 2023  ·  doi:10.1002/alz.13378

Maximizing the value of twin studies in health and behaviour

Fiona A. Hagenbeek, Jana S. Hirzinger, Sophie Breunig, Susanne Bruins, Dmitry V. Kuznetsov, Kirsten Schut, Veronika V. Odintsova, Dorret I. Boomsma

Nature Human Behaviour  ·  15 May 2023  ·  doi:10.1038/s41562-023-01609-6

Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes

Jeremy M. Lawrence, Sophie Breunig, Isabelle F. Foote, Connor B. Tallis, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  09 May 2023  ·  doi:10.1101/2023.04.29.23289281

The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson’s disease data

Hampton L. Leonard, Ruqaya Murtadha, Alejandro Martinez-Carrasco, Alina Jama, Amica Corda Müller-Nedebock, …, Mike A. Nalls, Sumit Dey, Sara Bandres-Ciga, Cornelis Blauwendraat, Alastair J. Noyce

npj Parkinson's Disease  ·  04 Mar 2023  ·  doi:10.1038/s41531-023-00472-6

Harnessing the potential of machine learning and artificial intelligence for dementia research

Janice M. Ranson, Magda Bucholc, Donald Lyall, Danielle Newby, Laura Winchester, …, Isabelle F. Foote, Vasiliki Orgeta, Andrey Kormilitzin, Ilianna Lourida, David J. Llewellyn

Brain Informatics  ·  24 Feb 2023  ·  doi:10.1186/s40708-022-00183-3

2022

The shared genetic architecture of modifiable risk for Alzheimer's disease: a genomic structural equation modelling study

Isabelle F Foote, Benjamin M Jacobs, Georgina Mathlin, Cameron J Watson, Phazha LK Bothongo, …, Ruth Dobson, Alastair J Noyce, Kamaldeep S Bhui, Ania Korszun, Charles R Marshall

Neurobiology of Aging  ·  01 Sep 2022  ·  doi:10.1016/j.neurobiolaging.2022.02.016

Polygenic Resilience Modulates the Penetrance of Parkinson Disease Genetic Risk Factors

Hui Liu, Mohammad Dehestani, Cornelis Blauwendraat, Mary B. Makarious, Hampton Leonard, …, Manu Sharma, Mike Nalls, Andrew Singleton, Thomas Gasser, Sara Bandres‐Ciga

Annals of Neurology  ·  24 Jun 2022  ·  doi:10.1002/ana.26416

Dementia risk in a diverse population: A single-region nested case-control study in the East End of London

Phazha L.K. Bothongo, Mark Jitlal, Eve Parry, Sheena Waters, Isabelle F. Foote, …, Ruth Dobson, Alastair J. Noyce, Naaheed Mukadam, Jonathan P. Bestwick, Charles R. Marshall

The Lancet Regional Health - Europe  ·  01 Apr 2022  ·  doi:10.1016/j.lanepe.2022.100321

2021

The Genetic Architecture of Alzheimer’s Disease Risk: A Genomic Structural Equation Modelling Study

Isabelle F Foote, Benjamin M Jacobs, Georgina Mathlin, Cameron J Watson, Phazha LK Bothongo, …, Ruth Dobson, Alastair J Noyce, Kamaldeep S Bhui, Ania Korszun, Charles R Marshall

Cold Spring Harbor Laboratory  ·  02 Mar 2021  ·  doi:10.1101/2021.02.23.21252211

2019

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Andrew D. Grotzinger, Mijke Rhemtulla, Ronald de Vlaming, Stuart J. Ritchie, Travis T. Mallard, …, Ian J. Deary, Philipp D. Koellinger, K. Paige Harden, Michel G. Nivard, Elliot M. Tucker-Drob

Nature Human Behaviour  ·  08 Apr 2019  ·  doi:10.1038/s41562-019-0566-x