Research

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Highlighted

Mapping the genetic landscape across 14 psychiatric disorders

Andrew D. Grotzinger, Josefin Werme, Wouter J. Peyrot, Oleksandr Frei, Christiaan de Leeuw, …, Hang Zhou, Peter Zill, Phil H. Lee, Kenneth S. Kendler, Jordan W. Smoller

Nature  ·  10 Dec 2025  ·  doi:10.1038/s41586-025-09820-3

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Andrew D. Grotzinger, Mijke Rhemtulla, Ronald de Vlaming, Stuart J. Ritchie, Travis T. Mallard, …, Ian J. Deary, Philipp D. Koellinger, K. Paige Harden, Michel G. Nivard, Elliot M. Tucker-Drob

Nature Human Behaviour  ·  08 Apr 2019  ·  doi:10.1038/s41562-019-0566-x

All

2025

Mapping the genetic landscape across 14 psychiatric disorders

Andrew D. Grotzinger, Josefin Werme, Wouter J. Peyrot, Oleksandr Frei, Christiaan de Leeuw, …, Hang Zhou, Peter Zill, Phil H. Lee, Kenneth S. Kendler, Jordan W. Smoller

Nature  ·  10 Dec 2025  ·  doi:10.1038/s41586-025-09820-3

Immune Markers Mediate Genetic Relationships between Immune Diseases and Psychiatric Disorders

Sophie Breunig, Kristen M Kelly, Lukas S Schaffer, Jeremy M Lawrence, Younga Heather Lee, Elizabeth W Karlson, Andrew David Grotzinger

Cold Spring Harbor Laboratory  ·  19 Oct 2025  ·  doi:10.1101/2025.10.17.25338241

Uncovering the multivariate genetic architecture of frailty with genomic structural equation modeling

Isabelle F. Foote, Jonny P. Flint, Anna E. Fürtjes, Jeremy M. Lawrence, Donncha S. Mullin, …, Janice M. Ranson, Simon R. Cox, Michelle Luciano, Kenneth Rockwood, Andrew D. Grotzinger

Nature Genetics  ·  01 Aug 2025  ·  doi:10.1038/s41588-025-02269-0

Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI

Anna E. Fürtjes, Isabelle F. Foote, Charley Xia, Gail Davies, Joanna Moodie, …, Michelle Luciano, W. David Hill, Ian J. Deary, Elliot M. Tucker-Drob, Simon R. Cox

Nature Communications  ·  21 Jul 2025  ·  doi:10.1038/s41467-025-61978-6

Examining the genetic links between clusters of immune-mediated diseases and psychiatric disorders

Sophie Breunig, Younga Heather Lee, Elizabeth W. Karlson, Arjun Krishnan, Jeremy M. Lawrence, Lukas S. Schaffer, Andrew D. Grotzinger

Translational Psychiatry  ·  21 Jul 2025  ·  doi:10.1038/s41398-025-03470-9

Examining the genetic relationship between Alzheimer’s disease, schizophrenia and their shared risk factors using genomic structural equation modelling

Inês Almeida e Sousa, Andrew D Grotzinger, Jeremy M Lawrence, Sophie Breunig, Charles R Marshall, Ania Korszun, Isabelle F Foote

Brain Communications  ·  01 Jan 2025  ·  doi:10.1093/braincomms/fcaf112

2024

Characterizing genetic pathways unique to autism spectrum disorder at multiple levels of biological analysis

Lukas S. Schaffer, Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Andrew D. Grotzinger

Molecular Autism  ·  15 Oct 2024  ·  doi:10.1186/s13229-024-00624-2

Shared Genetic Liability across Systems of Psychiatric and Physical Illness

Jeremy M. Lawrence, Isabelle F. Foote, Sophie Breunig, Lukas S. Schaffer, Travis T. Mallard, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  04 Aug 2024  ·  doi:10.1101/2024.08.02.24311427

Examining the Genetic Links between Clusters of Immune-mediated Diseases and Psychiatric Disorders

Sophie Breunig, Younga Heather Lee, Elizabeth W. Karlson, Arjun Krishnan, Jeremy M. Lawrence, Lukas S. Schaffer, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  19 Jul 2024  ·  doi:10.1101/2024.07.18.24310651

Characterizing Genetic Pathways Unique to Autism Spectrum Disorder at Multiple Levels of Biological Analysis

Lukas S. Schaffer, Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  09 Jun 2024  ·  doi:10.1101/2024.06.07.24308616

Examining Differences in the Genetic and Functional Architecture of Attention-Deficit/Hyperactivity Disorder Diagnosed in Childhood and Adulthood

Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Hannah J. Gebhardt, Erik G. Willcutt, Andrew D. Grotzinger

Biological Psychiatry Global Open Science  ·  01 May 2024  ·  doi:10.1016/j.bpsgos.2024.100307

2023

Genomic SEM applied to explore etiological divergences in bipolar subtypes

Jeremy M. Lawrence, Sophie Breunig, Isabelle F. Foote, Connor B. Tallis, Andrew D. Grotzinger

Psychological Medicine  ·  27 Oct 2023  ·  doi:10.1017/s0033291723002957

Examining Differences in the Genetic and Functional Architecture of ADHD Diagnosed in Childhood and Adulthood

Sophie Breunig, Jeremy M. Lawrence, Isabelle F. Foote, Hannah J. Gebhardt, Erik G. Willcutt, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  07 Aug 2023  ·  doi:10.1101/2023.08.02.23293439

Genomic SEM Applied to Explore Etiological Divergences in Bipolar Subtypes

Jeremy M. Lawrence, Sophie Breunig, Isabelle F. Foote, Connor B. Tallis, Andrew D. Grotzinger

Cold Spring Harbor Laboratory  ·  09 May 2023  ·  doi:10.1101/2023.04.29.23289281

2019

Genomic structural equation modelling provides insights into the multivariate genetic architecture of complex traits

Andrew D. Grotzinger, Mijke Rhemtulla, Ronald de Vlaming, Stuart J. Ritchie, Travis T. Mallard, …, Ian J. Deary, Philipp D. Koellinger, K. Paige Harden, Michel G. Nivard, Elliot M. Tucker-Drob

Nature Human Behaviour  ·  08 Apr 2019  ·  doi:10.1038/s41562-019-0566-x